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Nanomedicine Faces Barriers – PubMed Central (PMC)
28/10/2010 · Until tumours reach a certain degree of malignancy, and a certain size, they do not disturb nearby intact vascular barriers [177,178]. Furthermore, even tumours with generalised breakdown of the blood-tissue barriers, such as large tumours, have important regions, for example the growing/migrating leading edges of the tumour mass, which reside behind intact vascular barriers ( Figure 4 ).
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